| http://purl.uniprot.org/citations/16284450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16284450 | http://www.w3.org/2000/01/rdf-schema#comment | "To evaluate the effects of bisphenol A (BPA), a candidate endocrine disruptor (ED), on embryonic development, we examined the mRNA expression levels of the aryl hydrocarbon receptor (AhR; which binds with many EDs and plays crucial roles in their metabolism) and related factors [aryl hydrocarbon receptor repressor (AhRR) and AhR nuclear translocator (Arnt)], xenobiotic metabolizing enzymes [XMEs; cytochrome P450 1A1 (CYP1A1) and UDP-glucuronosyltransferase, and the glutathione S-transferase Ya subunit (GST)], in murine embryos exposed in utero to BPA (0.02, 2, 200, and 20,000 microg/kg/day) and 17beta-estradiol (E2; 5 microg/kg/day, used as a positive control) at 6.5-13.5 or 6.5-17.5 days post coitum (dpc) using the quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) method. Protein levels of CYP1A1 and GST in embryonic livers were estimated by Western immunoblotting. Exposure in utero to BPA [0.02 (1/100 dose of environmental exposure), 2, 200, and 20,000 microg/kg/day] increased AhR mRNA expression in the cerebra, cerebella, and gonads (testes and ovaries) of male and female mid-and late-developmental stage (14.5- and 18.5-dpc, respectively) embryos. BPA dose-independently up-regulated the expression of AhRR and Arnt in mid- and late-stage embryos. BPA had no remarkable effect on the mRNA levels of XMEs in mid-stage embryos, but dose-dependently up-regulated the expression in late-stage embryos. Moreover, the protein levels of these enzymes in the livers of late-stage embryos were increased. The present findings revealed that exposure to BPA in utero disrupts the expression of AhR and related factors and of xenobiotic metabolizing enzymes, and that mid-stage embryos, in the organogenic stage, are sensitive to BPA."xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.org/dc/terms/identifier | "doi:10.1262/jrd.17026"xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/author | "Nishizawa H."xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/author | "Imanishi S."xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/author | "Manabe N."xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/name | "J Reprod Dev"xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/pages | "593-605"xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/title | "Effects of exposure in utero to bisphenol a on the expression of aryl hydrocarbon receptor, related factors, and xenobiotic metabolizing enzymes in murine embryos."xsd:string |
| http://purl.uniprot.org/citations/16284450 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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