| http://purl.uniprot.org/citations/16284618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16284618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16284618 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammalian cells, the enzymatic pathways involved in cytoplasmic mRNA decay are incompletely defined. In this study, we have used two approaches to disrupt activities of deadenylating and/or decapping enzymes to monitor effects on mRNA decay kinetics and trap decay intermediates. Our results show that deadenylation is the key first step that triggers decay of both wild-type stable and nonsense codon-containing unstable beta-globin mRNAs in mouse NIH3T3 fibroblasts. PAN2 and CCR4 are the major poly(A) nucleases active in cytoplasmic deadenylation that have biphasic kinetics, with PAN2 initiating deadenylation followed by CCR4-mediated poly(A) shortening. DCP2-mediated decapping takes place after deadenylation and may serve as a backup mechanism for triggering mRNA decay when initial deadenylation by PAN2 is compromised. Our findings reveal a functional link between deadenylation and decapping and help to define in vivo pathways for mammalian cytoplasmic mRNA decay."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1016"xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1016"xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Yamashita Y."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Yamashita Y."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Zhong Z."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Zhong Z."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Chang T.-C."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Chang T.-C."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Chen C.-Y.A."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Chen C.-Y.A."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Shyu A.-B."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/author | "Shyu A.-B."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/pages | "1054-1063"xsd:string |
| http://purl.uniprot.org/citations/16284618 | http://purl.uniprot.org/core/pages | "1054-1063"xsd:string |