| http://purl.uniprot.org/citations/16286015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16286015 | http://www.w3.org/2000/01/rdf-schema#comment | "Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-alpha/beta and -lambda. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-alpha/beta and -lambda induction via TLR-7, TLR-8, and TLR-9 was abolished in IRAK-4-deficient blood cells. In contrast, IFN-alpha/beta and -lambda were induced normally by TLR-3 and TLR-4 agonists. Moreover, IFN-beta and -lambda were normally induced by TLR-3 agonists and viruses in IRAK-4-deficient fibroblasts. We further show that IFN-alpha/beta and -lambda production in response to 9 of 11 viruses tested was normal or weakly affected in IRAK-4-deficient blood cells. Thus, IRAK-4-deficient patients may control viral infections by TLR-3- and TLR-4-dependent and/or TLR-independent production of IFNs. The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2005.09.016"xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Ozinsky A."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Casanova J.L."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Roifman C."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Geissmann F."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "von Bernuth H."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Picard C."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Marodi L."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Jouanguy E."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Eidenschenk C."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Puel A."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Casrouge A."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Coffman R.L."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Al-Hajjar S."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Al-Ghonaium A."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Lebon P."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Chapel H."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Miller R.L."xsd:string |
| http://purl.uniprot.org/citations/16286015 | http://purl.uniprot.org/core/author | "Ku C.L."xsd:string |