| http://purl.uniprot.org/citations/16286919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16286919 | http://www.w3.org/2000/01/rdf-schema#comment | "The innate immune system recognizes nucleic acids during infection or tissue damage; however, the mechanisms of intracellular recognition of DNA have not been fully elucidated. Here we show that intracellular administration of double-stranded B-form DNA (B-DNA) triggered antiviral responses including production of type I interferons and chemokines independently of Toll-like receptors or the helicase RIG-I. B-DNA activated transcription factor IRF3 and the promoter of the gene encoding interferon-beta through a signaling pathway that required the kinases TBK1 and IKKi, whereas there was substantial activation of transcription factor NF-kappaB independent of both TBK and IKKi. IPS-1, an adaptor molecule linking RIG-I and TBK1, was involved in B-DNA-induced activation of interferon-beta and NF-kappaB. B-DNA signaling by this pathway conferred resistance to viral infection in a way dependent on both TBK1 and IKKi. These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1282"xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Hemmi H."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Ludwig H."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Torii Y."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Sutter G."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Takeshita F."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/author | "Coban C."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/pages | "40-48"xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/title | "A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA."xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16286919 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16286919 |