| http://purl.uniprot.org/citations/16289117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16289117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16289117 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a member of the MAPKKK family of protein kinases, and is involved in intracellular signalling pathways stimulated by transforming growth factor beta, interleukin-1 and tumour necrosis factor-alpha. TAK1 is known to rely upon an additional protein, TAK1-binding protein 1 (TAB1), for complete activation. However, the molecular basis for this activation has yet to be elucidated. We have solved the crystal structure of a novel TAK1 chimeric protein and these data give insight into how TAK1 is activated by TAB1. Our results reveal a novel binding pocket on the TAK1 kinase domain whose shape complements that of a unique alpha-helix in the TAK1 binding domain of TAB1, providing the basis for an intimate hydrophobic association between the protein activator and its target."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2005.09.098"xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2005.09.098"xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Cheetham G.M.T."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Cheetham G.M.T."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Dedi N."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Dedi N."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Vial S.C."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Vial S.C."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Dunster N.J."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Dunster N.J."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Long J.M."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/author | "Long J.M."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/pages | "1013-1020"xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/pages | "1013-1020"xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/title | "Structural basis for the interaction of TAK1 kinase with its activating protein TAB1."xsd:string |
| http://purl.uniprot.org/citations/16289117 | http://purl.uniprot.org/core/title | "Structural basis for the interaction of TAK1 kinase with its activating protein TAB1."xsd:string |