| http://purl.uniprot.org/citations/16289642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16289642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16289642 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs) . They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs . Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA . Our biochemical analysis revealed that Ago2 is present in a pre-miRNA processing complex that is able to transfer the miRNA into a target-mRNA cleaving complex. To gain insight into the function and composition of RNA silencing complexes, we purified Ago1- and Ago2-containing complexes from human cells. Several known Ago1-and/or Ago2-associated proteins including Dicer were identified, but also two novel factors, the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required to mediate miRNA-guided mRNA cleavage."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.10.048"xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.10.048"xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Peters L."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Peters L."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Meister G."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Meister G."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Urlaub H."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Urlaub H."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Chen P.Y."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Chen P.Y."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Landthaler M."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Landthaler M."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/pages | "2149-2155"xsd:string |
| http://purl.uniprot.org/citations/16289642 | http://purl.uniprot.org/core/pages | "2149-2155"xsd:string |