| http://purl.uniprot.org/citations/16291790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16291790 | http://www.w3.org/2000/01/rdf-schema#comment | "The alignment of the left-right (LR) body axis relative to the anteroposterior (AP) and dorsoventral (DV) axes is central to the organization of the vertebrate body plan and is controlled by the node/organizer. Somitogenesis plays a key role in embryo morphogenesis as a principal component of AP elongation. How morphogenesis is coupled to axis specification is not well understood. We demonstrate that Wnt3a is required for LR asymmetry. Wnt3a activates the Delta/Notch pathway to regulate perinodal expression of the left determinant Nodal, while simultaneously controlling the segmentation clock and the molecular oscillations of the Wnt/beta-catenin and Notch pathways. We provide evidence that Wnt3a, expressed in the primitive streak and dorsal posterior node, acts as a long-range signaling molecule, directly regulating target gene expression throughout the node and presomitic mesoderm. Wnt3a may also modulate the symmetry-breaking activity of mechanosensory cilia in the node. Thus, Wnt3a links the segmentation clock and AP axis elongation with key left-determining events, suggesting that Wnt3a is an integral component of the trunk organizer."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02149"xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/author | "Tsukiyama T."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/author | "Rawls J.A."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/author | "Biris K."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/author | "Nakaya M.A."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/author | "Yamaguchi T.P."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/author | "Jaime S."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/pages | "5425-5436"xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/title | "Wnt3a links left-right determination with segmentation and anteroposterior axis elongation."xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/16291790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16291790 |
| http://purl.uniprot.org/citations/16291790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16291790 |
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