| http://purl.uniprot.org/citations/16291940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16291940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16291940 | http://www.w3.org/2000/01/rdf-schema#comment | "Serotonin (5-HT) is a neuromodulator that regulates many aspects of animal behavior, including mood, aggression, sex drive, and sleep. In vertebrates, most of the behavioral effects of 5-HT appear to be mediated by G-protein-coupled receptors (GPCRs). Here, we show that SER-1 is the 5-HT GPCR responsible for the stimulatory effects of exogenous 5-HT in two sexually dimorphic behaviors of Caenorhabditis elegans, egg laying and male ventral tail curling. Loss of ser-1 function leads to decreased egg laying in hermaphrodites and defects in the turning step of mating behavior in males. ser-1 is expressed in muscles that are postsynaptic to serotonergic neurons and are known to be required for these behaviors. Analysis of the ser-1 mutant also reveals an inhibitory effect of 5-HT on egg laying that is normally masked by SER-1-dependent stimulation. This inhibition of egg laying requires MOD-1, a 5-HT-gated chloride channel. Loss of mod-1 function in males also produces defects in ventral tail curling and enhances the turning defects in ser-1 mutant males. Sustained elevations in 5-HT levels result in behavioral adaptation to both the stimulatory and inhibitory actions of the neurotransmitter, indicating that both SER-1 and MOD-1 signaling can be modulated. Removal of wild-type animals from high levels of exogenous 5-HT produces a SER-1-dependent withdrawal response in which egg laying is significantly decreased. These studies provide insight into the role of 5-HT in behavior and the regulation of 5-HT(2) receptor function."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3399-05.2005"xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3399-05.2005"xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "McIntire S.L."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "McIntire S.L."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "Hong S.W."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "Hong S.W."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "Carnell L."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "Carnell L."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "Illi J."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/author | "Illi J."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/pages | "10671-10681"xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/pages | "10671-10681"xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/title | "The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/title | "The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16291940 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16291940 |
| http://purl.uniprot.org/citations/16291940 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16291940 |