| http://purl.uniprot.org/citations/16293754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/16293754 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics."xsd:string |
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| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/author | "Rickert M."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/author | "Rickert M."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/name | "Science"xsd:string |
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| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/pages | "1159-1163"xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/title | "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/title | "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/volume | "310"xsd:string |
| http://purl.uniprot.org/citations/16293754 | http://purl.uniprot.org/core/volume | "310"xsd:string |
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