| http://purl.uniprot.org/citations/16294014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16294014 | http://www.w3.org/2000/01/rdf-schema#comment | "Prohibitin has been connected to diverse cellular functions including cell cycle control, senescence, apoptosis and stabilization of mitochondrial proteins. By employing a loss of function approach using siRNAs we have demonstrated an unexpected role of PHB in the activation of Raf/MEK/ERK pathway by active Ras and in modulating epithelial cell adhesion and migration. PHB directly interacts with C-Raf and is required for the displacement of 14-3-3 from C-Raf by active Ras to facilitate plasma membrane localization and activation. Further, the adherent complex proteins cadherin and beta-catenin were localized to plasma membrane suggesting stabilized adherent junctions in PHB silenced cells. Our findings demonstrated a function of PHB in the control of a central signaling pathway involved in cell growth and malignant transformation."xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.4.11.2142"xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/author | "Rudel T."xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/author | "Rajalingam K."xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/pages | "1503-1505"xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/title | "Ras-Raf signaling needs prohibitin."xsd:string |
| http://purl.uniprot.org/citations/16294014 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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