| http://purl.uniprot.org/citations/16294029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16294029 | http://www.w3.org/2000/01/rdf-schema#comment | "The cyclin dependent kinase inhibitor Sic1 and the cyclin Clb5 are essential regulators of the cyclin dependent kinase Cdc28 during the G1 to S transition in budding yeast. Yeast enters S phase after ubiquitin-mediated degradation of Sic1, an event triggered by Cln1, 2-Cdc28 mediated phosphorylation. We recently showed that Sic1 is involved in carbon source modulation of the critical cell size required to enter S phase. Here we show that the amount and sub-cellular localization of Sic1 are also carbon source-modulated. We identify a bipartite nuclear localization sequence responsible for nuclear localization of Sic1 and for correct cell cycle progression in a carbon-source dependent manner. Similarly to Cip/Kip proteins-Sic1 mammalian counterparts-Sic1 facilitates nuclear accumulation of its cognate cyclin, since cytoplasmic building-up of Clb5 is observed upon switching off expression of the SIC1 gene. Our data indicate a previously unrecognized inhibitor/activator dual role for Sic1 and put it among key molecules whose activity is regulated by their nuclear-cytoplasmic localization."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.4.12.2189"xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/author | "Vanoni M."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/author | "Alberghina L."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/author | "Rossi R.L."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/author | "Zinzalla V."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/author | "Mastriani A."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/pages | "1798-1807"xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/title | "Subcellular localization of the cyclin dependent kinase inhibitor Sic1 is modulated by the carbon source in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/16294029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16294029 |
| http://purl.uniprot.org/citations/16294029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16294029 |
| http://purl.uniprot.org/uniprot/P38634#attribution-7166487EDA6AB418C0658E101B24293F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16294029 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BZ98-mappedCitation-16294029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16294029 |
| http://purl.uniprot.org/uniprot/#_P38634-mappedCitation-16294029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16294029 |
| http://purl.uniprot.org/uniprot/#_P30283-mappedCitation-16294029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16294029 |
| http://purl.uniprot.org/uniprot/A0A8H4BZ98 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16294029 |
| http://purl.uniprot.org/uniprot/P38634 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16294029 |
| http://purl.uniprot.org/uniprot/P30283 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16294029 |