| http://purl.uniprot.org/citations/16297191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16297191 | http://www.w3.org/2000/01/rdf-schema#comment | "The HLA-Cw*0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw*0602 nor the allele CDSN*TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1_4_4 (OR = 2.6, 95% CI = 1.4-4.7, p(c) = 0.018) the octamer transcription factor (OTF)-3 gene (OR = 2.6, 95% CI = 1.6-4.3, p(c) = 0.0001) and the alpha-helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3-4.5, p(c) = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.0022-202x.2005.23892.x"xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/author | "Gonzalez S."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/author | "Lopez-Larrea C."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/author | "Brautbar C."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/author | "Lopez-Vazquez A."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/author | "Martinez-Borra J."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/author | "Enk C.D."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/pages | "928-932"xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/title | "The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population."xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16297191 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16297191 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-16297191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16297191 |
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| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-16297191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16297191 |