| http://purl.uniprot.org/citations/16297198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16297198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16297198 | http://www.w3.org/2000/01/rdf-schema#comment | "Leukocyte extravasation is a finely tuned process, in which transmigration is the final step. Transmigration depends on molecules located at borders of endothelial cells; e.g., junctional adhesion molecules (JAM-A, -B and -C). In vivo blockade of JAM-A lead to decreased migration of monocytes into the skin. In contrast, the role of JAM-B and -C in development of cutaneous inflammation is unknown. We therefore elicited an allergic contact dermatitis in mice using 2,4-dinitro-1-fluorobenzene. RT-PCR and immunofluorescent staining of healthy skin revealed a constitutive JAM-B (66.4%+/-6.7% of all vessels) and -C expression (88.6+/-13.2%), which remained constant after induction of contact dermatitis. Functional studies, in which either JAM-B or -C neutralizing antibodies were injected into sensitized mice prior to allergen challenge showed a concentration-dependent reduction of the contact dermatitis. Decreased ear swelling was accompanied by reduction of leukocyte infiltration as analyzed by hematoxylin and eosin (H&E) histology and enzyme activity. Combined antibody treatment at doses of 1.25 mg per kg bodyweight lead to additive inhibition of allergic contact dermatitis, indicating that JAM-B and -C may have distinct functions. In conclusion, interactions with JAM-B and -C are essential for development of cutaneous inflammation."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.0022-202x.2005.23912.x"xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.0022-202x.2005.23912.x"xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Hardt K."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Hardt K."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Pfeffer J."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Pfeffer J."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Santoso S."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Santoso S."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Kaufmann R."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Kaufmann R."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Radeke H.H."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Radeke H.H."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Baatz H."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Baatz H."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Boehncke W.H."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Boehncke W.H."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Gille J."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Gille J."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Johann P.S."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Johann P.S."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Ludwig R.J."xsd:string |
| http://purl.uniprot.org/citations/16297198 | http://purl.uniprot.org/core/author | "Ludwig R.J."xsd:string |