| http://purl.uniprot.org/citations/16297385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16297385 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleophosmin (NPM)/B23 is a multifunctional protein, involving in a wide variety of basic cellular processes, including ribosome assembly, DNA duplication, nucleocytoplasmic trafficking, and centrosome duplication. It has previously been shown that NPM/B23 localizes to centrosomes, and dissociate from centrosomes upon phosphorylation by Cdk2/cyclin E. However, detail characterization of centrosomal association of NPM/B23 has been hampered by the lack of appropriate antibodies that efficiently detects centrosomally localized NPM/B23, as well as by apparent loss of natural behavior of NPM/B23 when tagged with fluorescent proteins. Here, by the use of newly generated anti-NPM/B23 antibody, we conducted a careful analysis of centrosomal localization of NPM/B23. We found that NPM/B23 localizes between the paired centrioles of unduplicated centrosomes, suggesting the role of NPM/B23 in the centriole pairing. Upon initiation of centrosome duplication, some NPM/B23 proteins remain at mother centrioles of the parental centriole pairs. We further found that inhibition of Crm1 nuclear export receptor results in both accumulation of cyclin E at centrosomes and efficient dissociation of NPM/B23 from centrosomes."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.10.057"xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/author | "Fukasawa K."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/author | "Tokuyama Y."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/author | "Shinmura K."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/author | "Tarapore P."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/author | "George K.R."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/pages | "6621-6634"xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/title | "Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity."xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://purl.uniprot.org/core/volume | "579"xsd:string |
| http://purl.uniprot.org/citations/16297385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16297385 |
| http://purl.uniprot.org/citations/16297385 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16297385 |
| http://purl.uniprot.org/uniprot/Q61937#attribution-0D36C961DDE237AD3CB7CE93CAA04704 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16297385 |
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| http://purl.uniprot.org/uniprot/Q6P5F9#attribution-0D36C961DDE237AD3CB7CE93CAA04704 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16297385 |
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| http://purl.uniprot.org/uniprot/#_A3KGV1-mappedCitation-16297385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16297385 |
| http://purl.uniprot.org/uniprot/#_A3KGV2-mappedCitation-16297385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16297385 |
| http://purl.uniprot.org/uniprot/#_A3KGV3-mappedCitation-16297385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16297385 |
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| http://purl.uniprot.org/uniprot/#_A3KGW0-mappedCitation-16297385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16297385 |