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| http://purl.uniprot.org/citations/16297908 | http://www.w3.org/2000/01/rdf-schema#comment | "Human wild type (WT) and mutant alpha-synuclein (alpha-syn) genes were overexpressed using a Tet-on expression system in stably transfected dopaminergic MN9D cells. Their overexpression induced caspase-independent and dopamine-related apoptosis not rescued by general caspase inhibitor Z-VAD-FMK. While apoptosis due to overexpression of WT alpha-syn was completely abrogated by a specific tyrosine hydroxylase (TH) inhibitor, alpha-methyl-p-tyrosine (alpha-MT), the inhibitor only partially rescued apoptosis caused by overexpression of alpha-syn mutants. In addition, overexpression of mutants enhanced the toxicity of 1-methyl-4-phenylpyridinium (MPP+) and 6-hydroxyldopamine (6-OHDA) to MN9D cells, whereas overexpression of WT protected MN9D cells against MPP+ toxicity, but not against 6-OHDA. We conclude that WT alpha-syn is beneficial to dopaminergic neurons but its overexpression in the presence of endogenous dopamine makes it a potential threat to the cells. In contrast, mutant alpha-syn not only caused the loss of WT protective function but also the gain-of-toxicity which becomes more serious in the presence of dopamine and neurotoxins."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2005.10.012"xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/author | "Zhou Z.D."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/author | "Lim T.M."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/author | "Gung A.Y."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/author | "Ang S.T."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/author | "Leong S.M."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/author | "Yap B.P."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/pages | "156-170"xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/title | "Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein."xsd:string |
| http://purl.uniprot.org/citations/16297908 | http://purl.uniprot.org/core/volume | "312"xsd:string |
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