| http://purl.uniprot.org/citations/16301112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301112 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho-LIM-kinase (LIMK) signaling pathway, believed to be involved in the regulation of tumor invasion, specifically regulates the activity of cofilin. However, it is unclear whether cofilin plays a pivotal role in tumor invasiveness. In this paper we show using a tet-on gene expression system that over-expression of cofilin inhibits the invasiveness of human lung cancer H1299 cells. Over-expressed cofilin disrupts the actin cytoskeleton at the leading edge of the cell and up-regulates p27(kip1), which is known to be involved in regulating cell motility. Removal of cofilin over-expression normalizes the p27(kip1) level and concomitantly restores the invasiveness of the cultured cells. These findings suggest that excessive cofilin production might prevent cancer cell invasion."xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellbi.2005.07.005"xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/author | "Lee Y.J."xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/author | "Yun Z."xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/author | "Keng P.C."xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/author | "Mazzatti D.J."xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/pages | "877-883"xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/title | "Inhibition of invasiveness of human lung cancer cell line H1299 by over-expression of cofilin."xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/16301112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16301112 |
| http://purl.uniprot.org/citations/16301112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16301112 |
| http://purl.uniprot.org/uniprot/#_B4E112-mappedCitation-16301112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/#_G3V1A4-mappedCitation-16301112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/#_P23528-mappedCitation-16301112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/#_V9HWI5-mappedCitation-16301112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/P23528 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/V9HWI5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/B4E112 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16301112 |
| http://purl.uniprot.org/uniprot/G3V1A4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16301112 |