| http://purl.uniprot.org/citations/16301330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301330 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane protein amyloid-beta precursor protein (APP) and the vesicle-associated protein c-Jun NH(2)-terminal kinase-interacting protein-1 (JIP-1) are transported into axons by kinesin-1. Both proteins may bind to kinesin-1 directly and can be transported separately. Because JIP-1 and APP can interact, kinesin-1 may recruit them as a complex, enabling their cotransport. In this study, we tested whether APP and JIP-1 are transported together or separately on different vesicles. We found that, within the cellular context, JIP-1 preferentially interacts with Thr(668)-phosphorylated APP (pAPP), compared with nonphosphorylated APP. In neurons, JIP-1 colocalizes with vesicles containing pAPP and is excluded from those containing nonphosphorylated APP. The accumulation of JIP-1 and pAPP in neurites requires kinesin-1, and the expression of a phosphomimetic APP mutant increases JIP-1 transport. Down-regulation of JIP-1 by small interfering RNA specifically impairs transport of pAPP, with no effect on the trafficking of nonphosphorylated APP. These results indicate that the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP."xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200502043"xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/author | "Muresan V."xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/author | "Muresan Z."xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/pages | "615-625"xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/title | "Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1."xsd:string |
| http://purl.uniprot.org/citations/16301330 | http://purl.uniprot.org/core/volume | "171"xsd:string |
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| http://purl.uniprot.org/uniprot/P33175#attribution-C2E89AA3458C0C566A00E01FB0E99285 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301330 |
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