| http://purl.uniprot.org/citations/16301649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301649 | http://www.w3.org/2000/01/rdf-schema#comment | "During the adaptive phase of an immune response, naive B cells receive multiple signals to become activated. Among them are the engagement of the B cell Ag receptor and stimulation by cytokines. Specifically for an anti-microbial response, the recognition of viral or bacterial Ags by the BCR and the stimulation of IFN-gamma result in the predominant production of IgG2a. The T-bet protein has been shown to be required for class switching to IgG2a. In this report we further investigated the regulation of T-bet gene expression during the early stage of B cell activation. We show that there is a striking synergistic activation of T-bet in primary B cells when both the BCR and IFN-gamma signaling pathways are activated. The synergistic activation of T-bet correlates with a 100% increase in the number of B cells that produce IgG2a. This transcription synergy on T-bet is transient in the first 24 h of B cell activation. Furthermore, we demonstrate that the synergistic activation of T-bet is dependent on Stat1 and that Stat1 is required for the IgG2a germline transcription and the production of IgG2a in response to the simultaneous signaling of BCR and IFN-gamma. Finally, we show that Stat1 directly regulates the expression of T-bet by binding to the T-bet promoter. These results reveal the mechanism of regulation of T-bet expression and uncover a novel physiological function of Stat1 for B cell activation."xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.11.7419"xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/author | "Zhang J.J."xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/pages | "7419-7424"xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/title | "Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation."xsd:string |
| http://purl.uniprot.org/citations/16301649 | http://purl.uniprot.org/core/volume | "175"xsd:string |
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