| http://purl.uniprot.org/citations/16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301743 | http://www.w3.org/2000/01/rdf-schema#comment | "Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II-deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon beta (IFNbeta) gene. Here, we found that the F4/80-positive macrophages in DNase II(-/-) fetal liver specifically produce a set of cytokines such as IFNbeta, TNFalpha, and CXCL10. Whereas, IFN-inducible genes (2'5'-oligo(A) synthetase, IRF7, and ISG15) were expressed not only in macrophages but also in other F4/80-negative cells. When DNase II(-/-) macrophages or embryonal fibroblasts engulfed apoptotic cells, they expressed the IFNbeta and CXCL10 genes. The ablation of Toll-like receptor (TLR) 3 and 9, or their adaptor molecules (MyD88 and TRIF), had no effect on the lethality of the DNase II(-/-) mice. These results indicate that there is a TLR-independent sensing mechanism to activate the innate immunity for the endogenous DNA escaping lysosomal degradation."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20051654"xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/author | "Nagata S."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/author | "Okabe Y."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/author | "Kawane K."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/pages | "1333-1339"xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/title | "Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation."xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/16301743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16301743 |
| http://purl.uniprot.org/citations/16301743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16301743 |
| http://purl.uniprot.org/uniprot/#_D3Z5U3-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_P56542-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA2-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VI41-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS40-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSY9-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-16301743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301743 |