| http://purl.uniprot.org/citations/16301747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301747 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell antigen receptor (BCR)-mediated activation of IkappaB kinase (IKK) and nuclear factor-kappaB require protein kinase C (PKC)beta; however, the mechanism by which PKCbeta regulates IKK is unclear. Here, we demonstrate that another protein kinase, TGFbeta-activated kinase (TAK)1, is essential for IKK activation in response to BCR stimulation. TAK1 interacts with the phosphorylated CARMA1 (also known as caspase recruitment domain [CARD]11, Bimp3) and this interaction is mediated by PKCbeta. IKK is also recruited to the CARMA1-Bcl10-mucosal-associated lymphoid tissue 1 adaptor complex in a PKCbeta-dependent manner. Hence, our data suggest that phosphorylation of CARMA1, mediated by PKCbeta, brings two key protein kinases, TAK1 and IKK, into close proximity, thereby allowing TAK1 to phosphorylate IKK."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20051591"xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20051591"xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Sakurai H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Sakurai H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Shinohara H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Shinohara H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Aiba Y."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Aiba Y."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Sanjo H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Sanjo H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Watarai H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Watarai H."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Hamadate M."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/author | "Hamadate M."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/16301747 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |