| http://purl.uniprot.org/citations/16304053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16304053 | http://www.w3.org/2000/01/rdf-schema#comment | "Class 1 phosphoinositide 3-kinases (PI3Ks), consisting of PI3Kalpha, beta, gamma, and delta, are a family of intracellular signaling molecules that play important roles in cell-mediated immune responses. In thymocytes, however, their role is less clear, although PI3Kgamma is postulated to partially contribute to pre-TCR-dependent differentiation. We now report that PI3Kdelta, in conjunction with PI3Kgamma, is required for thymocyte survival and ultimately for T-cell production. Surprisingly, genetic deletion of the p110delta and p110gamma catalytic subunits resulted in a dramatic reduction in thymus size, cellularity, and lack of corticomedullary differentiation. Total thymocyte counts in these animals were 27-fold lower than in wild-type (WT) controls because of a diminished number of CD4+ CD8+ double-positive (DP) cells and were associated with T-cell depletion in blood and in secondary lymphoid organs. Moreover, this alteration in the DP population was intrinsic to thymocytes, because the reconstitution of p110gammadelta-/-animals with WT fetal liver cells restored the proportions of all thymocyte populations to those in WT controls. The observed defects were related to massive apoptosis in the DP population; TCRB expression, pre-TCR selection, and generation of DP cells appeared relatively unperturbed. Thus, class 1 PI3Ks work in concert to protect developing thymocytes from apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-08-3300"xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Douangpanya J."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Puri K."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Swat W."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Vermi W."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Doggett T.A."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Diacovo T.G."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/author | "Montgrain V."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/pages | "2415-2422"xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/title | "Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival."xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/16304053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16304053 |
| http://purl.uniprot.org/citations/16304053 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16304053 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8F6-mappedCitation-16304053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16304053 |
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| http://purl.uniprot.org/uniprot/#_B1AS26-mappedCitation-16304053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16304053 |
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| http://purl.uniprot.org/uniprot/#_O35904-mappedCitation-16304053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16304053 |