| http://purl.uniprot.org/citations/16306226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16306226 | http://www.w3.org/2000/01/rdf-schema#comment | "Maladaptive cardiac hypertrophy can progress to congestive heart failure, a leading cause of morbidity and mortality in the United States. A better understanding of the intracellular signal transduction network that controls myocyte cell growth may suggest new therapeutic directions. mAKAP is a scaffold protein that has recently been shown to coordinate signal transduction enzymes important for cytokine-induced cardiac hypertrophy. We now extend this observation and show mAKAP is important for adrenergic-mediated hypertrophy. One function of the mAKAP complex is to facilitate cAMP-dependent protein kinase A-catalyzed phosphorylation of the ryanodine receptor Ca2+-release channel. Experiments utilizing inhibition of the ryanodine receptor, RNA interference of mAKAP expression and replacement of endogenous mAKAP with a mutant form that does not bind to protein kinase A demonstrate that the mAKAP complex contributes to pro-hypertrophic signaling. Further, we show that calcineurin Abeta associates with mAKAP and that the formation of the mAKAP complex is required for the full activation of the pro-hypertrophic transcription factor NFATc. These data reveal a novel function of the mAKAP complex involving the integration of cAMP and Ca2+ signals that promote myocyte hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02675"xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/author | "Kapiloff M.S."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/author | "Michel J.J."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/author | "Bauman A.L."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/author | "Dodge-Kafka K.L."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/author | "Pare G.C."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/author | "McHenry M."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/pages | "5637-5646"xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/title | "The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/16306226 | http://purl.uniprot.org/core/volume | "118"xsd:string |
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