| http://purl.uniprot.org/citations/16306936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16306936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16306936 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferon (IFN) production is a critical component of the innate defence against viral infections. Viral products induce strong type I IFN responses through the activation of Toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as protein kinase R (PKR). Here we demonstrate that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several different TLRs. Furthermore, we show that TRAF3 associates with the TLR adaptors TRIF and IRAK1, as well as downstream IRF3/7 kinases TBK1 and IKK-epsilon, suggesting that TRAF3 serves as a critical link between TLR adaptors and downstream regulatory kinases important for IRF activation. In addition to TLR stimulation, we also show that TRAF3-deficient fibroblasts are defective in their type I IFN response to direct infection with vesicular stomatitis virus, indicating that TRAF3 is also an important component of TLR-independent viral recognition pathways. Our data demonstrate that TRAF3 is a major regulator of type I IFN production and the innate antiviral response."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04374"xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04374"xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Saha S.K."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Saha S.K."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Guo B."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Guo B."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Cheng G."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Cheng G."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Perry A."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Perry A."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "He J.Q."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "He J.Q."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Zarnegar B."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Zarnegar B."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Shahangian A."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Shahangian A."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Oganesyan G."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/author | "Oganesyan G."xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16306936 | http://purl.uniprot.org/core/name | "Nature"xsd:string |