| http://purl.uniprot.org/citations/16307838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16307838 | http://www.w3.org/2000/01/rdf-schema#comment | "T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species. In the present study, we have investigated the apoptotic effects of T-2 toxin on chondrocytes and the relationship between T-2 toxin induced chondrocyte apoptosis and its influence on Bcl-2/Bax protein and mRNA expression. We have also examined the inhibitory effects of selenium on chondrocyte apoptosis induced by T-2 toxin. We have combined morphological and biological techniques to establish the relevance of apoptosis in human chondrocyte death induced by T-2 toxin. Treatment with T-2 toxin caused accelerated apoptosis in a concentration dependent manner. The apoptosis induced by T-2 toxin involved an increased Bax/Bcl-2 ratio. Bcl-2 mRNA expression remained unchanged in chondrocyte apoptosis induced by T-2 toxin treatment, while Bax mRNA expression increased following treatment with T-2 toxin. Selenium could partly block the apoptosis of chondrocytes induced by T-2 toxin through decreasing the Bax/Bcl-2 ratio. These results suggest that, under our experimental conditions, apoptosis of chondrocytes can be induced by T-2 toxin (1-20ng/mL) via the Bcl-2 and Bax proteins, and the Bax/Bcl-2 ratio may play a critical role in governing the susceptibility to apoptosis induced by T-2 toxin in human chondrocytes."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.fct.2005.09.004"xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/author | "Cao J."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/author | "Chu Y."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/name | "Food Chem Toxicol"xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/pages | "567-573"xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/title | "T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio."xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/16307838 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16307838 |
| http://purl.uniprot.org/citations/16307838 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16307838 |
| http://purl.uniprot.org/uniprot/P10415#attribution-D0C8427944E2AFC75DD1A94D289B9C71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16307838 |
| http://purl.uniprot.org/uniprot/Q07812#attribution-D0C8427944E2AFC75DD1A94D289B9C71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16307838 |