| http://purl.uniprot.org/citations/16308562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16308562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16308562 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic cell proliferation is controlled by growth factors and essential nutrients. In their absence, cells may enter into a quiescent state (G0). In Saccharomyces cerevisiae, the conserved protein kinase A (PKA) and rapamycin-sensitive TOR (TORC1) pathways antagonize G0 entry in response to carbon and/or nitrogen availability primarily by inhibiting the PAS kinase Rim15 function. Here, we show that the phosphate-sensing Pho80-Pho85 cyclin-cyclin-dependent kinase (CDK) complex also participates in Rim15 inhibition through direct phosphorylation, thereby effectively sequestering Rim15 in the cytoplasm via its association with 14-3-3 proteins. Inactivation of either Pho80-Pho85 or TORC1 causes dephosphorylation of the 14-3-3-binding site in Rim15, thus enabling nuclear import of Rim15 and induction of the Rim15-controlled G0 program. Importantly, we also show that Pho80-Pho85 and TORC1 converge on a single amino acid in Rim15. Thus, Rim15 plays a key role in G0 entry through its ability to integrate signaling from the PKA, TORC1, and Pho80-Pho85 pathways."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600889"xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600889"xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Pedruzzi I."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Pedruzzi I."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Cameroni E."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Cameroni E."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "De Virgilio C."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "De Virgilio C."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Dubouloz F."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Dubouloz F."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Wanke V."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/author | "Wanke V."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/pages | "4271-4278"xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/pages | "4271-4278"xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/title | "Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/title | "Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex."xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/16308562 | http://purl.uniprot.org/core/volume | "24"xsd:string |