| http://purl.uniprot.org/citations/16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16314517 | http://www.w3.org/2000/01/rdf-schema#comment | "The multifunctional transcription factor TFII-I is tyrosine phosphorylated in response to extracellular growth signals and transcriptionally activates growth-promoting genes. However, whether activation of TFII-I also directly affects the cell cycle profile is unknown. Here we show that under normal growth conditions, TFII-I is recruited to the cyclin D1 promoter and transcriptionally activates this gene. Most strikingly, upon cell cycle arrest resulting from genotoxic stress and p53 activation, TFII-I is ubiquitinated and targeted for proteasomal degradation in a p53- and ATM (ataxia telangiectasia mutated)-dependent manner. Consistent with a direct role of TFII-I in cell cycle regulation and cellular proliferation, stable and ectopic expression of wild-type TFII-I increases cyclin D1 levels, resulting in accelerated entry to and exit from S phase, and overcomes p53-mediated cell cycle arrest, despite radiation. We further show that the transcriptional regulation of cyclin D1 and cell cycle control by TFII-I are dependent on its tyrosine phosphorylation at positions 248 and 611, sites required for its growth signal-mediated transcriptional activity. Taken together, our data define TFII-I as a growth signal-dependent transcriptional activator that is critical for cell cycle control and proliferation and further reveal that genotoxic stress-induced degradation of TFII-I results in cell cycle arrest."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.24.10940-10952.2005"xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Prives C."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Ahn J."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Desgranges Z.P."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Roy A.L."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Rosenberg N."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Ashworth T."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Lazebnik M.B."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/author | "Pestell R.C."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/pages | "10940-10952"xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/title | "Inhibition of TFII-I-dependent cell cycle regulation by p53."xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16314517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16314517 |
| http://purl.uniprot.org/citations/16314517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16314517 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314517 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314517 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314517 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314517 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314517 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-16314517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314517 |