| http://purl.uniprot.org/citations/16314522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16314522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16314522 | http://www.w3.org/2000/01/rdf-schema#comment | "The cell membrane receptor ErbB-2 migrates to the nucleus. However, the mechanism of its nuclear translocation is unclear. Here, we report a novel mechanism of its nuclear localization that involves interaction with the transport receptor importin beta1, nuclear pore protein Nup358, and a host of players in endocytic internalization. Knocking down importin beta1 using small interfering RNA oligonucleotides or inactivation of small GTPase Ran by RanQ69L, a dominant-negative mutant of Ran, causes a nuclear transport defect of ErbB-2. Mutation of a putative nuclear localization signal in ErbB-2 destroys its interaction with importin beta1 and arrests nuclear translocation, while inactivation of nuclear export receptor piles up ErbB-2 within the nucleus. Additionally, blocking of internalization by a dominant-negative mutant of dynamin halts its nuclear localization. Thus, the cell membrane-embedded ErbB-2, through endocytosis using the endocytic vesicle as a vehicle, importin beta1 as a driver and Nup358 as a traffic light, migrates from the cell surface to the nucleus. This novel mechanism explains how a receptor tyrosine kinase on the cell surface can be translocated into the nucleus. This pathway may serve as a general mechanism to allow direct communication between cell surface receptors and the nucleus, and our findings thus open a new era in understanding direct trafficking between the cell membrane and nucleus."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.24.11005-11018.2005"xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.24.11005-11018.2005"xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Wang S.C."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Wang S.C."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Li L.Y."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Li L.Y."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Bartholomeusz G."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Bartholomeusz G."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Lee D.F."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Lee D.F."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Ali-Seyed M."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Ali-Seyed M."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Giri D.K."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Giri D.K."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Ling P."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/author | "Ling P."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/16314522 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |