| http://purl.uniprot.org/citations/16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16314886 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the availability of effective antihypertensive drugs, there is a large variation in response to these drugs. This study investigates whether polymorphisms in the angiotensin converting enzyme (I/D), angiotensinogen (M235T), alpha-adducin (G460W), angiotensin II type 1 receptor (1166A/C), or G protein beta(3)-subunit (825C/T) gene modify the mean difference in blood pressure levels among diuretics, beta-blockers, or ACE-inhibitors users. Data were used from the Doetinchem Cohort Study, and blood pressure data were collected from GPs (1987-1997). A marginal generalized linear model (GEE) was used to assess the gene-drug interaction on the mean difference in systolic/diastolic blood pressure. In total, 625 hypertensive individuals were included with a total of 5262 measurements of blood pressure. Only the interaction between diuretic use and the GNB3 825C/T polymorphism was significant (C allele versus TT systolic blood pressure (SBP): 4.33 mmHg [95% CI: 0.14-8.54]). Thus, the mean SBP level among diuretic users may be modified by the GNB3 825C/T polymorphism."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.tpj.6500339"xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "Stricker B.H."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "Kroon A.A."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "Kromhout D."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "de Boer A."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "de Leeuw P.W."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "Klungel O.H."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "Verschuren W.M."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/author | "Schelleman H."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/name | "Pharmacogenomics J"xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/pages | "22-26"xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/title | "Interactions between five candidate genes and antihypertensive drug therapy on blood pressure."xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16314886 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16314886 |
| http://purl.uniprot.org/citations/16314886 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16314886 |
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| http://purl.uniprot.org/uniprot/#_A0A6Q8PF84-mappedCitation-16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314886 |
| http://purl.uniprot.org/uniprot/#_A0A804HL01-mappedCitation-16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314886 |
| http://purl.uniprot.org/uniprot/#_B4DPW4-mappedCitation-16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314886 |
| http://purl.uniprot.org/uniprot/#_P35611-mappedCitation-16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314886 |
| http://purl.uniprot.org/uniprot/#_F1T0G4-mappedCitation-16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314886 |
| http://purl.uniprot.org/uniprot/#_F1T0G5-mappedCitation-16314886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16314886 |