| http://purl.uniprot.org/citations/16316627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16316627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16316627 | http://www.w3.org/2000/01/rdf-schema#comment | "UnpEL (also known as Usp4 or Unph) is an oncogenic protein, because its expression with a strong promoter results in the tumorigenic transformation of NIH3T3 cells injected into nude mice. Although the structure of UnpEL is that of a deubiquitinating enzyme, neither its precise function in mammalian cells nor the mechanism of UnpEL-mediated tumorigenesis is known. Here, we show that UnpEL functions as a deubiquitinating enzyme in human HEK293T cells and its isopeptidase activity deconjugates ubiquitin specifically from a UnpEL-interacting protein Ro52. We further show that UnpEL translocates to the cytoplasmic rod-like structures and colocalizes with Ro52 when Ro52 is overexpressed in HEK293 cells. These results suggest that UnpEL colocalizes with the unubiquitinated form of Ro52 to the cytoplasmic rod-like structures, where it keeps Ro52 unubiquitinated. The continuous deubiquitination of Ro52 might be involved in tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.11.076"xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.11.076"xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/author | "Wada K."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/author | "Wada K."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/author | "Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/author | "Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/author | "Tanji K."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/author | "Tanji K."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/pages | "731-736"xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/pages | "731-736"xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/title | "Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/title | "Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity."xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/volume | "339"xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://purl.uniprot.org/core/volume | "339"xsd:string |
| http://purl.uniprot.org/citations/16316627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16316627 |
| http://purl.uniprot.org/citations/16316627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16316627 |
| http://purl.uniprot.org/citations/16316627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16316627 |
| http://purl.uniprot.org/citations/16316627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16316627 |