| http://purl.uniprot.org/citations/16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16317090 | http://www.w3.org/2000/01/rdf-schema#comment | "Human early thymic precursors have the potential to differentiate into multiple cell lineages, including T cells and plasmacytoid dendritic cells (pDCs). This decision is guided by the induction or silencing of lineage-specific transcription factors. The ETS family member Spi-B is a key regulator of pDC development, whereas T-cell development is critically dependent on GATA-3. Here we show that triggering of the Notch1 signaling pathway by Delta-like1 controls the T/pDC lineage decision by regulating the balance between these factors. CD34+ CD1a-thymic progenitor cells express Notch1, but down-regulate this receptor when differentiating into pDCs. On coculture with stromal cell lines expressing either human Delta-like1 (DL1) or Jagged1 (Jag1) Notch ligands, thymic precursors express GATA-3 and develop into CD4+ CD8+ TCRalphabeta+ T cells. On the other hand, DL1, but not Jag1, down-regulates Spi-B expression, resulting in impaired development of pDCs. The Notch1-induced block in pDC development can be relieved through the ectopic expression of Spi-B. These data indicate that DL1-induced activation of the Notch1 pathway controls the lineage commitment of early thymic precursors by altering the levels between Spi-B and GATA-3."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-05-2090"xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Nagasawa M."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Spits H."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Gimeno R."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Blom B."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Dontje W."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Schotte R."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Cupedo T."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/author | "Scheeren F."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/pages | "2446-2452"xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/title | "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B."xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/16317090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16317090 |
| http://purl.uniprot.org/citations/16317090 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16317090 |
| http://purl.uniprot.org/uniprot/#_A0A384P5C6-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |
| http://purl.uniprot.org/uniprot/#_B4DP71-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |
| http://purl.uniprot.org/uniprot/#_H6VYP0-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |
| http://purl.uniprot.org/uniprot/#_H6VYP1-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |
| http://purl.uniprot.org/uniprot/#_H9BDU9-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |
| http://purl.uniprot.org/uniprot/#_H9CXX2-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |
| http://purl.uniprot.org/uniprot/#_P23771-mappedCitation-16317090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16317090 |