| http://purl.uniprot.org/citations/16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16319895 | http://www.w3.org/2000/01/rdf-schema#comment | "The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligase that, by targeting protein substrates for 26S proteasome-mediated degradation through ubiquitination, coordinates the temporal progression of eukaryotic cells through mitosis and the subsequent G1 phase of the cell cycle. Other functions of the APC/C are, however, less well defined. Here we show that two APC/C components, APC5 and APC7, interact directly with the coactivators CBP and p300 through protein-protein interaction domains that are evolutionarily conserved in adenovirus E1A. This interaction stimulates intrinsic CBP/p300 acetyltransferase activity and potentiates CBP/p300-dependent transcription. We also show that APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation. Furthermore, we establish that CBP is required in APC/C function; specifically, gene ablation of CBP by RNA-mediated interference markedly reduces the E3 ubiquitin ligase activity of the APC/C and the progression of cells through mitosis. Taken together, our results define discrete roles for the APC/C-CBP/p300 complexes in growth regulation."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04151"xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Martin A."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Turnell A.S."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Yamano H."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Stewart G.S."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Gallimore P.H."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Rookes S.M."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/author | "Grand R.J."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/pages | "690-695"xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/title | "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression."xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://purl.uniprot.org/core/volume | "438"xsd:string |
| http://purl.uniprot.org/citations/16319895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16319895 |
| http://purl.uniprot.org/citations/16319895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16319895 |
| http://purl.uniprot.org/uniprot/#_B4DFK4-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |
| http://purl.uniprot.org/uniprot/#_A5D8X2-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |
| http://purl.uniprot.org/uniprot/#_A8KAQ7-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |
| http://purl.uniprot.org/uniprot/#_B3KMP2-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |
| http://purl.uniprot.org/uniprot/#_B7Z6Z3-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |
| http://purl.uniprot.org/uniprot/#_F5H0F9-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |
| http://purl.uniprot.org/uniprot/#_Q2M2R1-mappedCitation-16319895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16319895 |