| http://purl.uniprot.org/citations/16319926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16319926 | http://www.w3.org/2000/01/rdf-schema#comment | "Nociceptors, or pain-sensitive receptors, are unique among sensory receptors in that their sensitivity is increased by noxious stimulation. This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1. Several different mechanisms for sensitization of TRPV1 have been proposed. Here we show that NGF, acting on the TrkA receptor, activates a signalling pathway in which PI3 kinase plays a crucial early role, with Src kinase as the downstream element which binds to and phosphorylates TRPV1. Phosphorylation of TRPV1 at a single tyrosine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most of the rapid sensitizing actions of NGF."xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600893"xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/author | "McNaughton P.A."xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/pages | "4211-4223"xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/title | "NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels."xsd:string |
| http://purl.uniprot.org/citations/16319926 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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