| http://purl.uniprot.org/citations/16324150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16324150 | http://www.w3.org/2000/01/rdf-schema#comment | "The TRAP220 subunit of the thyroid hormone receptor-associated polypeptide transcription coactivator complex (TRAP/Mediator complex), mammalian counterpart of the yeast Mediator complex, is proposed to act on a variety of major and specific biological events through physical interactions with nuclear receptors. The vitamin D receptor (VDR) and retinoic acid receptor (RAR), coupled with retinoid X receptor (RXR), are nuclear receptors which have important roles for monopoiesis and granulopoiesis, respectively. In this study, we present the functional role of TRAP220 in nuclear receptor-mediated monopoiesis and granulopoiesis. The mouse Trap220(-/-) yolk sac hematopoietic progenitor cells were resistant to 1,25-dihydroxyvitamin D(3)-stimulated differentiation into monocytes/macrophages. Furthermore, flow cytometric analyses showed that HL-60 cells, human promyelocytic leukemia cell line, wherein TRAP220 was down-regulated, did not differentiate efficiently into monocytes and granulocytes by stimulation with 1,25-dihydroxyvitamin D(3) and all-trans retinoic acid, correspondingly. The expression of direct target genes of VDR or RAR, as well as the differentiation marker genes, was low in the knockdown cells. These results indicated a crucial role of TRAP220 in the optimal VDR- and RAR-mediated myelomonocytic differentiation processes in mammalian hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2005.00906.x"xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Yamamoto K."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Chihara K."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Urahama N."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Minagawa K."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Okamura A."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Yakushijin K."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Sada A."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/author | "Hato A."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/pages | "1127-1137"xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/title | "The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation."xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/16324150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16324150 |
| http://purl.uniprot.org/citations/16324150 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16324150 |
| http://purl.uniprot.org/uniprot/Q925J9#attribution-F7CBF97C74B67566E6D17885391BB954 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16324150 |
| http://purl.uniprot.org/uniprot/#_B1AQH6-mappedCitation-16324150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16324150 |
| http://purl.uniprot.org/uniprot/#_Q925J9-mappedCitation-16324150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16324150 |
| http://purl.uniprot.org/uniprot/Q925J9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16324150 |