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http://purl.uniprot.org/citations/16325153http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (LTP), spatial learning, and depression. Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning. Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during postnatal development display impaired learning and LTP.

Methods

To examine whether there is a link among impaired hippocampal synaptic plasticity, altered spines, and trkB receptors, we performed a quantitative analysis of spine densities and spine length in the hippocampal area CA1 and the dentate gyrus in conditional mutant mice (trkB(lox/lox)CaMKII-CRE mice). TrkB protein and mRNA levels were assayed using Western blot and in situ hybridization analysis.

Results

Fifteen-week-old mutant mice exhibit specific reductions in spine densities and a significant increase in spine length of apical and basal dendrites in area CA1. These alterations correlate with a time- and region-specific reduction in full-length trkB mRNA in the hippocampus.

Conclusions

TrkB functions in structural remodeling of hippocampal dendritic spines, which in turn may affect synaptic transmission and plasticity."xsd:string
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http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/author"Krause S."xsd:string
http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/author"Medina D."xsd:string
http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/author"Unsicker K."xsd:string
http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/author"Minichiello L."xsd:string
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http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/author"von Bohlen und Halbach O."xsd:string
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http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/title"Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies."xsd:string
http://purl.uniprot.org/citations/16325153http://purl.uniprot.org/core/volume"59"xsd:string
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