| http://purl.uniprot.org/citations/16325765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16325765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16325765 | http://www.w3.org/2000/01/rdf-schema#comment | "TipE is an auxiliary subunit of the Drosophila Para sodium channel. Here we describe four sequences, TEH1-4, homologous to TipE in the Drosophila melanogaster genome, harboring all typical structures of both TipE and the beta-Subunit family of big-conductance Ca(2+)-activated potassium channels: short cytosolic N- and C-terminal stretches, two transmembrane domains, and a large extracellular loop with two disulfide bonds. Whereas TEH1 and TEH2 lack the TipE-specific extension in the extracellular loop, both TEH3 and TEH4 possess two extracellular EGF-like domains. A CNS-specific expression was found for TEH1, while TEH2-4 were more widely expressed. The genes for TEH2-4 are localized close to the tipE gene on chromosome 3L. Coexpression of TEH subunits with Para in Xenopus oocytes showed a strong (30-fold, TEH1), medium (5-to 10-fold, TEH2 and TEH3), or no (TEH4) increase in sodium current amplitude, while TipE increased the current 20-fold. In addition, steady-state inactivation and the recovery from fast inactivation were altered by coexpression of Para with TEH1. We conclude that members of the TEH-family are auxiliary subunits for Para sodium channels and possibly other ion channels."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.11.096"xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.11.096"xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Derst C."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Derst C."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Veh R.W."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Veh R.W."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Walther C."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Walther C."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Heinemann S.H."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Heinemann S.H."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Wicher D."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/author | "Wicher D."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/pages | "939-948"xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/pages | "939-948"xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/title | "Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/title | "Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE."xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/volume | "339"xsd:string |
| http://purl.uniprot.org/citations/16325765 | http://purl.uniprot.org/core/volume | "339"xsd:string |