| http://purl.uniprot.org/citations/16327802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16327802 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-13 is a major inducer of fibrosis in many chronic infectious and autoimmune diseases. In studies of the mechanisms underlying such induction, we found that IL-13 induces transforming growth factor (TGF)-beta(1) in macrophages through a two-stage process involving, first, the induction of a receptor formerly considered to function only as a decoy receptor, IL-13Ralpha(2). Such induction requires IL-13 (or IL-4) and tumor necrosis factor (TNF)-alpha. Second, it involves IL-13 signaling through IL-13Ralpha(2) to activate an AP-1 variant containing c-jun and Fra-2, which then activates the TGFB1 promoter. In vivo, we found that prevention of IL-13Ralpha(2) expression reduced production of TGF-beta(1) in oxazolone-induced colitis and that prevention of IL-13Ralpha(2) expression, Il13ra2 gene silencing or blockade of IL-13Ralpha(2) signaling led to marked downregulation of TGF-beta(1) production and collagen deposition in bleomycin-induced lung fibrosis. These data suggest that IL-13Ralpha(2) signaling during prolonged inflammation is an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1332"xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/author | "Puri R.K."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/author | "Strober W."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/author | "Kitani A."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/author | "Fichtner-Feigl S."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/pages | "99-106"xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/title | "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis."xsd:string |
| http://purl.uniprot.org/citations/16327802 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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