| http://purl.uniprot.org/citations/16327805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16327805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16327805 | http://www.w3.org/2000/01/rdf-schema#comment | "Cdk7 performs two essential but distinct functions as a CDK-activating kinase (CAK) required for cell-cycle progression and as the RNA polymerase II (Pol II) CTD kinase of general transcription factor IIH. To investigate the substrate specificity underlying this dual function, we created an analog-sensitive (AS) Cdk7 able to use bulky ATP derivatives. Cdk7-AS-cyclin H-Mat1 phosphorylates approximately 10-15 endogenous polypeptides in nuclear extracts. We identify seven of these as known and previously unknown Cdk7 substrates that define two classes: proteins such as Pol II and transcription elongation factor Spt5, recognized efficiently only by the fully activated Cdk7 complex, through sequences surrounding the site of phosphorylation; and CDKs, targeted equivalently by all active forms of Cdk7, dependent on substrate motifs remote from the phosphoacceptor residue. Thus, Cdk7 accomplishes dual functions in cell-cycle control and transcription not through promiscuity but through distinct, stringent modes of substrate recognition."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1028"xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1028"xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Blethrow J.D."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Blethrow J.D."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Fisher R.P."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Fisher R.P."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Barboza N.M."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Barboza N.M."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Batliner J."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Batliner J."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Gamble M.J."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Gamble M.J."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Kraybill B.C."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Kraybill B.C."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Larochelle S."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/author | "Larochelle S."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16327805 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |