| http://purl.uniprot.org/citations/16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16328057 | http://www.w3.org/2000/01/rdf-schema#comment | "The MLL-AF9 oncogene originates from the translocation t(9;11)(p22;q23), which is mainly associated with monocytic acute myeloid leukaemia (AML-M5; FAB-classification). In AML-M5 THP-1 cells carrying t(9;11) (p22;q23) and expressing MLL-AF9, we previously showed that MLL-AF9 expression is down-regulated during monocyte-macrophage maturation. We have subsequently observed that in a 'rapid-growing' variant of the THP-1 cell line (THP-1-R) MLL-AF9 down-regulation does not occur. MLL fusion proteins (including MLL-AF9) deregulate MYC transactivation activity, and both presence and absence of MYC down-regulation have been reported during monocyte-macrophage maturation in THP-1 cells. In the present study, we analyze the expression patterns of MLL-AF9, MLL wild-type and MYC after induction of monocyte-macrophage terminal differentiation in the AML-M5 cell lines, THP-1, THP-1-R, Mono-Mac-6 (MM6) and MOLM-13, all of which carry t(9;11)(p22;q23) and express MLL-AF9. RT-PCR analysis indicated that down-regulation of MLL-AF9, MLL or MYC is not necessary to abolish malignant phenotypes by induction of terminal monocyte-macrophage differentiation in leukaemic cells carrying t(9;11)(p22;q23)."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Pession A."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Tonelli R."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Martino V."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Marino F."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Franzoni M."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Fazzina R."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/author | "Montemurro L."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/pages | "207-211"xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/title | "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)."xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/16328057 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16328057 |
| http://purl.uniprot.org/citations/16328057 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16328057 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SF09-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z448-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z449-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |
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| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-16328057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16328057 |