Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/16332259http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16332259http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16332259http://www.w3.org/2000/01/rdf-schema#comment"

Background

Vertebrate odorant receptors comprise three types of G protein-coupled receptors: the OR, V1R and V2R receptors. The OR superfamily contains over 1,000 genes in some mammalian species, representing the largest gene superfamily in the mammalian genome.

Results

To facilitate an informed analysis of OR gene phylogeny, we identified the complete set of 143 OR genes in the zebrafish genome, as well as the OR repertoires in two pufferfish species, fugu (44 genes) and tetraodon (42 genes). Although the genomes analyzed here contain fewer genes than in mammalian species, the teleost OR genes can be grouped into a larger number of major clades, representing greater overall OR diversity in the fish.

Conclusion

Based on the phylogeny of fish and mammalian repertoires, we propose a model for OR gene evolution in which different ancestral OR genes or gene families were selectively lost or expanded in different vertebrate lineages. In addition, our calculations of the ratios of non-synonymous to synonymous codon substitutions among more recently expanding OR subgroups in zebrafish implicate residues that may be involved in odorant binding."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.org/dc/terms/identifier"doi:10.1186/1471-2164-6-173"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.org/dc/terms/identifier"doi:10.1186/1471-2164-6-173"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/author"Ngai J."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/author"Ngai J."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/author"Alioto T.S."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/author"Alioto T.S."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/name"BMC Genomics"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/name"BMC Genomics"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/pages"173"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/pages"173"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/title"The odorant receptor repertoire of teleost fish."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/title"The odorant receptor repertoire of teleost fish."xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/16332259http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/16332259http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16332259
http://purl.uniprot.org/citations/16332259http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16332259
http://purl.uniprot.org/citations/16332259http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16332259
http://purl.uniprot.org/citations/16332259http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16332259
http://purl.uniprot.org/uniprot/O42165http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/16332259
http://purl.uniprot.org/uniprot/Q2PRH0http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/16332259
▶