| http://purl.uniprot.org/citations/16339077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16339077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16339077 | http://www.w3.org/2000/01/rdf-schema#comment | "Rap1 is a small GTPase that regulates adherens junction maturation. It remains elusive how Rap1 is activated upon cell-cell contact. We demonstrate for the first time that Rap1 is activated upon homophilic engagement of vascular endothelial cadherin (VE-cadherin) at the cell-cell contacts in living cells and that MAGI-1 is required for VE-cadherin-dependent Rap1 activation. We found that MAGI-1 localized to cell-cell contacts presumably by associating with beta-catenin and that MAGI-1 bound to a guanine nucleotide exchange factor for Rap1, PDZ-GEF1. Depletion of MAGI-1 suppressed the cell-cell contact-induced Rap1 activation and the VE-cadherin-mediated cell-cell adhesion after Ca2+ switch. In addition, relocation of vinculin from cell-extracellular matrix contacts to cell-cell contacts after the Ca2+ switch was inhibited in MAGI-1-depleted cells. Furthermore, inactivation of Rap1 by overexpression of Rap1GAPII impaired the VE-cadherin-dependent cell adhesion. Collectively, MAGI-1 is important for VE-cadherin-dependent Rap1 activation upon cell-cell contact. In addition, once activated, Rap1 upon cell-cell contacts positively regulate the adherens junction formation by relocating vinculin that supports VE-cadherin-based cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-07-0647"xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Yamagishi A."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Yamagishi A."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Sakurai A."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Sakurai A."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Masuda M."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Masuda M."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Sako K."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Sako K."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Kamioka Y."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Kamioka Y."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Nakaoka Y."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/author | "Nakaoka Y."xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/16339077 | http://purl.uniprot.org/core/pages | "966-976"xsd:string |