| http://purl.uniprot.org/citations/16339527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16339527 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin A affects many aspects of T lymphocyte development and function. The vitamin A metabolites all-trans- and 9-cis-retinoic acid regulate gene expression by binding to the retinoic acid receptor (RAR), while 9-cis-retinoic acid also binds to the retinoid X receptor (RXR). Naive DO11.10 T lymphocytes expressed mRNA and protein for RAR-alpha, RXR-alpha, and RXR-beta. DNA microarray analysis was used to identify RXR-responsive genes in naive DO11.10 T lymphocytes treated with the RXR agonist AGN194204. A total of 128 genes was differentially expressed, including 16 (15%) involved in cell growth or apoptosis. Among these was Bcl2a1, an antiapoptotic Bcl2 family member. Quantitative real-time PCR analysis confirmed this finding and demonstrated that Bcl2a1 mRNA expression was significantly greater in nonapoptotic than in apoptotic T lymphocytes. The RXR agonist 9-cis-retinoic acid also increased Bcl2a1 expression, although all-trans-retinoic acid and ligands for other RXR partner receptors did not. Treatment with AGN194204 and 9-cis-retinoic acid significantly decreased apoptosis measured by annexin V staining but did not affect expression of Bcl2 and Bcl-xL. Bcl2a1 promoter activity was examined using a luciferase promoter construct. Both AGN194204 and 9-cis-retinoic acid significantly increased luciferase activity. In summary, these data demonstrate that RXR agonists increase Bcl2a1 promoter activity and increase expression of Bcl2a1 in naive T lymphocytes but do not affect Bcl2 and Bcl-xL expression in naive T lymphocytes. Thus, this effect on Bcl2a1 expression may account for the decreased apoptosis seen in naive T lymphocytes treated with RXR agonists."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.12.7916"xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/author | "Stephensen C.B."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/author | "Xiao J.H."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/author | "Rasooly R."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/author | "Chandraratna R.A."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/author | "Gregg J.P."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/author | "Schuster G.U."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/pages | "7916-7929"xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/title | "Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16339527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16339527 |
| http://purl.uniprot.org/citations/16339527 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16339527 |
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| http://purl.uniprot.org/uniprot/Q07440 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16339527 |
| http://purl.uniprot.org/uniprot/Q4FK02 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16339527 |
| http://purl.uniprot.org/uniprot/Q8K164 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16339527 |