| http://purl.uniprot.org/citations/16339967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16339967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16339967 | http://www.w3.org/2000/01/rdf-schema#comment | "The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the nucleoplasm. The LEM domain mediates binding to a DNA-crosslinking protein, barrier-to-autointegration factor (BAF). We describe a novel, ubiquitously expressed LEM domain protein, LEM2, which is structurally related to MAN1. LEM2 contains an N-terminal LEM motif, two predicted transmembrane domains and a MAN1-Src1p C-terminal (MSC) domain highly homologous to MAN1, but lacks the MAN1-specific C-terminal RNA-recognition motif. Immunofluorescence microscopy of digitonin-treated cells and subcellular fractionation identified LEM2 as a lamina-associated protein residing in the INM. LEM2 binds to the lamin C tail in vitro. Targeting of LEM2 to the nuclear envelope requires A-type lamins and is mediated by the N-terminal and transmembrane domains. Highly overexpressed LEM2 accumulates in patches at the nuclear envelope and forms membrane bridges between nuclei of adjacent cells. LEM2 structures recruit A-type lamins, emerin, MAN1 and BAF, whereas lamin B and lamin B receptor are excluded. Our data identify LEM2 as a novel A-type-lamin-associated INM protein involved in nuclear structure organization."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02701"xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02701"xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Brachner A."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Brachner A."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Foisner R."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Foisner R."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Gotzmann J."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Gotzmann J."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Reipert S."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/author | "Reipert S."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/pages | "5797-5810"xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/pages | "5797-5810"xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/title | "LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/title | "LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins."xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/16339967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16339967 |
| http://purl.uniprot.org/citations/16339967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16339967 |