| http://purl.uniprot.org/citations/16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16341126 | http://www.w3.org/2000/01/rdf-schema#comment | "One notable phenotypic change during the differentiation of immature thymocytes into either mature CD4 or CD8 single-positive lineages is the acquisition of a resistance to glucocorticoid (GC)-induced apoptosis. We have previously reported that SRG3 is critical in determining the sensitivity for the GC-induced apoptosis in developing thymocytes. We report here that Notch signaling downregulates the transcriptional activation of SRG3 through N-box and/or E-box elements on its promoter. RBP-J represses SRG3 transcription through the N-box motif. On the other hand, Deltex1 competitively inhibits the binding of p300 to E2A/HEB protein bound to the E-box elements and represses the SRG3 promoter activity. Moreover, enforced expression of Deltex1 restored double-positive (DP) thymocyte survival from the GC-induced apoptosis. Our results suggest that Notch signaling confers differentiating DP thymocytes resistance to GCs by regulating the SRG3 expression through Deltex1, and that Deltex1 and SRG3 may play a significant role during DP thymocyte maturation."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401827"xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Choi Y.I."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Jang J."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Chung H."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Seong R.H."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/author | "Jeon S.H."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/pages | "1495-1505"xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/title | "Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter."xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16341126 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16341126 |
| http://purl.uniprot.org/citations/16341126 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16341126 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTV5-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVE0-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_E9Q7W0-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_Q6R5E9-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_P31266-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_Q3U6F1-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_Q5DTK6-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |
| http://purl.uniprot.org/uniprot/#_Q3UM17-mappedCitation-16341126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16341126 |