| http://purl.uniprot.org/citations/16341225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16341225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16341225 | http://www.w3.org/2000/01/rdf-schema#comment | "Decapping is a key step in both general and nonsense-mediated 5' --> 3' mRNA-decay pathways. Removal of the cap structure is catalyzed by the Dcp1-Dcp2 complex. The crystal structure of a C-terminally truncated Schizosaccharomyces pombe Dcp2p reveals two distinct domains: an all-helical N-terminal domain and a C-terminal domain that is a classic Nudix fold. The C-terminal domain of both Saccharomyces cerevisiae and S. pombe Dcp2p proteins is sufficient for decapping activity, although the N-terminal domain can affect the efficiency of Dcp2p function. The binding of Dcp2p to Dcp1p is mediated by a conserved surface on its N-terminal domain, and the N-terminal domain is required for Dcp1p to stimulate Dcp2p activity. The flexible nature of the N-terminal domain relative to the C-terminal domain suggests that Dcp1p binding to Dcp2p may regulate Dcp2p activity through conformational changes of the two domains."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1033"xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1033"xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Chen N."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Chen N."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Parker R."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Parker R."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Decker C.J."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Decker C.J."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "She M."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "She M."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Tumati S."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/author | "Tumati S."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/pages | "63-70"xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/pages | "63-70"xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/title | "Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/16341225 | http://purl.uniprot.org/core/title | "Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe."xsd:string |