| http://purl.uniprot.org/citations/16341228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16341228 | http://www.w3.org/2000/01/rdf-schema#comment | "The SWI/SNF (mating-type switch/sucrose nonfermenting) complex involved in chromatin remodeling on promoters has also been detected on the coding region of genes. Here we show that SWI/SNF can function as a regulator of alternative splicing. We found that the catalytic subunit Brm favors inclusion of variant exons in the mRNA of several genes, including E-cadherin, BIM, cyclin D1 and CD44. Consistent with this, Brm associates with several components of the spliceosome and with Sam68, an ERK-activated enhancer of variant exon inclusion. Examination of the CD44 gene revealed that Brm induced accumulation of RNA polymerase II (RNAPII) with a modified CTD phosphorylation pattern on regions encoding variant exons. Altogether, our data suggest that on genes regulated by SWI/SNF, Brm contributes to the crosstalk between transcription and RNA processing by decreasing RNAPII elongation rate and facilitating recruitment of the splicing machinery to variant exons with suboptimal splice sites."xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1030"xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/author | "Yaniv M."xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/author | "Batsche E."xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/author | "Muchardt C."xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/pages | "22-29"xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/title | "The human SWI/SNF subunit Brm is a regulator of alternative splicing."xsd:string |
| http://purl.uniprot.org/citations/16341228 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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