| http://purl.uniprot.org/citations/16342117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16342117 | http://www.w3.org/2000/01/rdf-schema#comment | "The ultimobranchial body (UBB) is an outpocketing of the fourth pharyngeal pouch that fuses with the thyroid diverticulum, giving rise to calcitonin-producing C-cells. In this study, we demonstrate that the UBB is composed of two types of cells: one expressing T/ebp/Nkx2.1 and the other expressing p63. The former cell type, accounting for a majority of the UBB, requires T/ebp/Nkx2.1 for their survival. In contrast, the p63-positive cells, even in the absence of T/ebp/Nkx2.1 expression, can proliferate and give rise to a vesicular structure that is lined by a monolayer of p63-negative cells, surrounded by a cluster and/or single layer of p63-positive cells, displaying the basal/stem cell phenotype. T/ebp/Nkx2.1 haploinsufficiency causes abnormal fusion of the UBB with the thyroid diverticulum, which stays as a cluster of C-cells around the vesicular structure, similar to the one observed in mice null for T/ebp/Nkx2.1 expression. These results demonstrate that T/ebp/Nkx2.1 plays a role in the survival of UBB cells, their dissemination into the thyroid diverticulum, and the formation of UBB-derived vesicular structure."xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.20655"xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/author | "Kusakabe T."xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/author | "Hoshi N."xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/pages | "1300-1309"xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/title | "Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid."xsd:string |
| http://purl.uniprot.org/citations/16342117 | http://purl.uniprot.org/core/volume | "235"xsd:string |
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