| http://purl.uniprot.org/citations/16343421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16343421 | http://www.w3.org/2000/01/rdf-schema#comment | "Mdm2 promotes ubiquitination of the tumor suppressor p53 and can function as an oncogene by largely downregulating p53. Although a p53-independent role of Mdm2 has been reported, the underlying mechanism remains unclear. In the present study, we indicated that Mdm2 is involved in p53-independent carcinogenesis via downregulation of pRB. Expression of pRB showed an apparent inverse correlation with Mdm2 expression in 30 patients with non-small cell lung cancer. There were some cases with the p53 mutations in which a high level of Mdm2 and a low level of pRB were expressed. Mdm2 promoted ubiquitination of pRB in cells without wild-type p53. Furthermore, pRB-mediated G1 arrest in a p53-deficient cell line, SRB1, was significantly enhanced by a mutant Mdm2 that lacks pRB ubiquitination activity. Soft-agar colony formation activity of p53-knockout MEF was increased by wild-type Mdm2 but not mutant Mdm2. These findings suggest that overexpression of Mdm2 can perturb a RB pathway regardless of the p53 gene status, promoting carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.11.148"xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Oda T."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Kitagawa M."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Yasuda H."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Miwa S."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Hattori T."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Kitagawa K."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Uchida C."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Sugimura H."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/author | "Chida K."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/pages | "54-61"xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/title | "Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner."xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/16343421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16343421 |
| http://purl.uniprot.org/citations/16343421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16343421 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-16343421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16343421 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-16343421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16343421 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-16343421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16343421 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-16343421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16343421 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-16343421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16343421 |