http://purl.uniprot.org/citations/16344721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16344721 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveNonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a decreased risk of colorectal tumors. Single nucleotide polymorphisms (SNPs) in target genes of NSAID action, and their haplotypes, might modulate this protective effect.MethodsA case-control study including 724 cases and 682 controls was used to evaluate the effect of NSAIDs on colorectal adenoma risk in The Netherlands, a country in which NSAID use is relatively low. Cases and controls were classified according to presence or absence of endoscopy-proven, pathology-confirmed colorectal adenomas, ever in their lives. Thirteen SNPs in four genes (PPARdelta, PPARgamma, PTGS1 and PTGS2) were genotyped in 787 subjects (384 cases and 403 controls).ResultsCompared to non-regular users (< 12 times/year), regular users of NSAIDs (> or = 12 times/year) had a lower risk of colorectal adenomas (odds ratio (OR): 0.75, 95% confidence interval (CI): 0.56-0.99). The results were similar for aspirin only. We found an interaction between SNP c.-789C>T in PPARdelta and NSAID use (P=0.03). The protective effect of NSAIDs was strengthened for regular users with the PPARdelta CT or TT genotypes (OR: 0.35, 95%CI: 0.11-1.13), whereas a positive association was observed for non-regular users with these genotypes (OR: 2.24, 95%CI: 1.06-4.73) as compared to non-regular users with the CC genotype. Also, a statistically significant interaction between a major haplotype containing the minor allele of this SNP and NSAID use was observed.ConclusionsThis study confirms the protective effect of NSAIDs and suggests a modulating effect of a SNP in the promoter of PPARdelta."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.fpc.0000182778.03180.f3"xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "Fodde R."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "van Kranen H.J."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "de Jong D.J."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "Kampman E."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "Kram N.R."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "Siezen C.L."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "Tijhuis M.J."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/author | "van Soest E.M."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/name | "Pharmacogenet Genomics"xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/pages | "43-50"xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/title | "Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta."xsd:string |
http://purl.uniprot.org/citations/16344721 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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