http://purl.uniprot.org/citations/16351648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16351648 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo investigate the prognostic and predictive relevance of p53 protein, Ki-67 antigen, MMP-2 and MMP-9 in patients with transitional cell carcinoma (TCC) of the upper urinary tract.MethodsThe expression of p53 protein, Ki-67 antigen, MMP-2 and MMP-9 was examined by immunohistochemistry in 69 patients with TCC of the upper urinary tract. Correlation of p53, Ki-67, MMP-2 and MMP-9 over-expression with conventional pathological parameters and patient survival was examined.Resultsp53 over-expression was significantly correlated with histological grade (P < 0.05), but not with pathological stage, vascular invasion, lymphatic invasion or lymph node metastasis. Ki-67 over-expression was significantly correlated with stage, grade, lymphatic invasion and vascular invasion (P < 0.05). In survival analyses, Ki-67 over-expression was a significant prognostic factor in the univariate analysis (P < 0.05), but it did not have a significant impact on survival in the multivariate analysis. Ki-67 labeling index was a significant prognostic factor in patients with a low p53 labeling index, but not in patients with a high p53 labeling index.ConclusionKi-67 over-expression is of prognostic value in TCC of the upper urinary tract, while p53, MMP-2 and MMP-9 are of limited value."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1442-2042.2005.01159.x"xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Ito H."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Ichikawa T."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Tobe T."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Igarashi T."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Suyama T."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/author | "Kamijima S."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/name | "Int J Urol"xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/pages | "941-947"xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/title | "The prognostic value of p53, Ki-67 and matrix metalloproteinases MMP-2 and MMP-9 in transitional cell carcinoma of the renal pelvis and ureter."xsd:string |
http://purl.uniprot.org/citations/16351648 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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