| http://purl.uniprot.org/citations/16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16352536 | http://www.w3.org/2000/01/rdf-schema#comment | "Injury to neurons after West Nile virus (WNV) infection is believed to occur because of viral and host immune-mediated effects. Previously, we demonstrated that CD8+ T cells are required for the resolution of WNV infection in the central nervous system (CNS). CD8+ T cells can control infection by producing antiviral cytokines (e.g., gamma interferon or tumor necrosis factor alpha) or by triggering death of infected cells through perforin- or Fas ligand-dependent pathways. Here, we directly evaluated the role of perforin in controlling infection of a lineage I New York isolate of WNV in mice. A genetic deficiency of perforin molecules resulted in higher viral burden in the CNS and increased mortality after WNV infection. In the few perforin-deficient mice that survived initial challenge, viral persistence was observed in the CNS for several weeks. CD8+ T cells required perforin to control WNV infection as adoptive transfer of WNV-primed wild-type but not perforin-deficient CD8+ T cells greatly reduced infection in the brain and spinal cord and enhanced survival of CD8-deficient mice. Analogous results were obtained when wild-type or perforin-deficient CD8+ T cells were added to congenic primary cortical neuron cultures. Taken together, our data suggest that despite the risk of immunopathogenesis, CD8+ T cells use a perforin-dependent mechanism to clear WNV from infected neurons."xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.80.1.119-129.2006"xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/author | "Samuel M.A."xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/author | "Diamond M.S."xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/author | "Shrestha B."xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/pages | "119-129"xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/title | "CD8+ T cells require perforin to clear West Nile virus from infected neurons."xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/16352536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16352536 |
| http://purl.uniprot.org/citations/16352536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16352536 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16352536 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16352536 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16352536 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16352536 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16352536 |
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| http://purl.uniprot.org/uniprot/#_P04223-mappedCitation-16352536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16352536 |